Three men were convicted of their roles in the “sophisticated” global online darknet drug business.
Colin McCabe, 39-old, Toby Woods, 36-old, and Robert Price have raised more than £ 1 million selling Class A drugs on the dark web, Thames police said.
The network was discovered by the FBI, which then contacted the UK police.
The Aylesbury Royal Court heard that the trio used the bitcoin cryptocurrency to evade detection and sold drugs even in Australia.
Leader McCabe of Carr Close, Aylesbury, Buckinghamshire, was jailed for 12 years after confessing to conspiracy to supply drugs including cocaine, ketamine and cannabis.
Price of Richmond Road, Layton Buzzard, Bedfordshire, was jailed for nine years and nine months after pleading guilty to conspiracy to supply drugs.
Woods of Rowland Way, Aylesbury, was sentenced to 14 months after pleading to acquire or control the property of criminals.
The court heard that the group was selling drugs under the Project4 brand, and their clients were paying for them in bitcoin.
In sentencing, Judge Francis Sheridan said he had never had to deal with a drug supply operation “as complex or well-organized as this.”
He said that the fact that payments were made in bitcoins, including through the darknet, was another attempt to avoid hijacking.